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Potential New Treatment Targets for Alzheimer's

A research team has uncovered potential novel treatment targets for Alzheimer's disease, as well as existing drugs that have therapeutic potential to be repurposed against these targets.
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Drug Screen Reveals 7 Potential Inhibitors of SARS-CoV-2 Replication

A research group has identified seven potential repurposed drugs for COVID-19 treatment through virtual screening and cell-based assays.
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Liver Drug Candidates Discovered Among Pesticides

A team of biologists and chemists has discovered unlikely drug candidates, for treating liver fibrosis and other pathologies, among pest control chemicals.
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Tuning the Immune System May Enhance Vaccines

Immunologists have identified a biological pathway that selectively controls how T follicular helper cells mature into functional components of the immune system.
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Enzyme Inhibitor Boosts Immune System To Fight Antibiotic-Resistant Bacteria

Researchers from Johns Hopkins University discover an enzyme inhibitor that boosts the immune system to fight methicillin-resistant Staphylococcus aureus (MRSA) and other skin infections.
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Using AI To Assess Biological Activity of Natural Products

Researchers have shown how artificial intelligence methods can be used to find new pharmaceutical applications for natural products.
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New Synthetic Circuits Rely on Protein Interactions, Not Transcription and Translation

MIT synthetic biologists have now developed an alternative approach to designing synthetic circuits, which relies exclusively on fast, reversible protein-protein interactions. This means that there's no waiting for genes to be transcribed or translated into proteins, so circuits can be turned on much faster, within seconds.
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Approach Identifies Drugs That Can "Glue" Proteins Together

Researchers have developed a novel drug screening method that can test the effectiveness of therapeutic molecules designed to "glue" proteins together.
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Slowing Down Huntington’s Disease With Gene Therapy

In a new study on mice, Johns Hopkins Medicine researchers report that using MRI scans to measure blood volume in the brain can serve as a noninvasive way to potentially track the progress of gene editing therapies for early-stage Huntington’s disease, a neurodegenerative disorder that attacks brain cells.
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Considerations When Designing COVID-19 Drug Trials

A new modeling study suggests that randomization, early patient enrollment and treatment initiation in clinical trials are key points to consider when identifying effective antiviral drugs against SARS-CoV-2.
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