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Finding Drugs To Target Critical Enzymes Called Racemases
Scientists have explored racemases, enzymes linked to certain cancers that are critical to cell function, and have proposed new strategies for finding drugs that neutralize these enzymes.
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A Novel Class of Radiosensitizers for Glioblastoma
Researchers have shown that the calcium channel blocker (CCB), mibefradil, inhibits DNA repair independent of its CCB activity. The findings could lead to a new class of mibefradil-based DNA repair inhibitors for glioblastoma.
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Fungi and Bacteria Can Activate Genes Linked to Head and Neck Cancer
An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance.
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Non-Hallucinogenic Psychedelic Analog Reverses Effects of Stress in Mice
A compound with a similar structure to the psychedelic drug ibogaine, but lacking its toxic and hallucinogenic effects, has been shown to reverse the effects of stress in mice.
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Type 1 Diabetes Vaccine May Be Effective for Certain Subgroups
A clinical study led by Linköping University has investigated whether immunotherapy against type 1 diabetes can preserve the body's own production of insulin.
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Polymer-Based Membrane Improves Controlled Release of Drugs
Researchers demonstrate that a membrane created from threads of a type of polymer used in vascular sutures can be loaded with drugs and implanted in the body. Once administered mechanical forces activate the polymer's electric potential triggering the slow release of the drugs.
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Reawakening Potent but Inert Anticancer Immune Cells
Scientists from Ludwig Cancer Research have discovered how to revive “terminally exhausted” tumor-infiltrating T lymphocytes (TILs) that are often found within tumors for cancer therapy.
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A Step Towards a Nasal Spray Treatment for Parkinson’s Disease
University of York researchers are developing a nasal spray treatment for patients with Parkinson’s disease.
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Optogenetic Therapy Partially Restores Vision in a Blind Patient
The results from a clinical trial using optogenetics to treat a patient with retinitis pigmentosae show that the therapy was able to partially restore visual function.
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Gene Signatures Underlying Plaque-Eating Microglia Are Discovered
Scientists have found the gene expression signatures underlying the engulfing of deposits of the amyloid-beta (Aβ) protein in the brain.
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