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Metformin Linked to Protection Against Skin Cancer, Study Finds
Metformin, widely prescribed for type 2 diabetes, may also protect against the two most common types of skin cancer.
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Artificial Ribozyme SAMURI Offers Insights Into RNA Therapeutics
Researchers have determined the 3D structure of SAMURI, an artificial ribozyme that precisely modifies RNA. Using S-adenosylmethionine (SAM) as a cofactor, SAMURI catalyzes targeted RNA changes critical for cellular function.
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Cannabinoid-Based Drug Restores Memory in Neurodegeneration Models
Research highlights the therapeutic potential of targeting cannabinoid receptors to counter memory impairment in early neurodegenerative diseases. A synthetic compound, WIN55.212-2, improved memory in rodent models by activating cannabinoid receptors
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Avian Flu Is Evolving, But Antiviral Treatments Remain Effective
Researchers at Texas Biomed identified nine mutations in a bird flu strain from a person in Texas. Bad news: this strain is more capable of causing disease and replicates better in the brain. Good news: approved antivirals are still effective.
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How Some Osteoporosis Drugs May Protect Against COVID-19
Researchers identified how bisphosphonates, used to treat osteoporosis, might reduce Covid-19 risks. Drugs such as alendronate and zoledronate bind to key viral enzyme domains, potentially lowering infection and hospitalization rates.
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Genetic Tweak Boosts Drug-Making Cells by Blocking Toxic Byproducts
Researchers have developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.
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PCT Blood Test Does Not Shorten Antibiotic Treatment for Hospitalized Children
A groundbreaking UK study has examined whether an additional blood test called procalcitonin (PCT) could safely shorten the time children spend on intravenous (IV) antibiotics in hospitals.
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How Specialized Cells Contribute to Blood Vessel Dysfunction
Researchers have uncovered how specialized cells surrounding small blood vessels, known as perivascular cells, contribute to blood vessel dysfunction in chronic diseases such as cancer, diabetes and fibrosis.
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Targeted Intervention Combats Bacterial Metabolism
Targeting a metabolic pathway that only occurs in bacteria offers a new avenue for antibiotic design.
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Self-Assembling Molecules Developed With Applications in Targeted Drug Discovery
A collaborative team has developed a new method to program molecular self-assembly predictably. Researchers created versatile materials like "Malteser molecules," which could serve as highly specific sensors or drug delivery agents.
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