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“Nuclear Speckles” Inside Cells May Play a Role in Some Cancers
Scientists have shed light on the functions of mysterious structures in cells called "nuclear speckles", showing that they can work in partnership with a key protein to enhance the activities of specific sets of genes.
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Clinical Trial Evaluating COVID-19 Variant Vaccine Begins
On February 24, the biotechnology company Moderna Therapeutics announced that it had shipped its variant-specific COVID-19 vaccine candidate, mRNA-1273.351, to the National Institutes of Health (NIH) for clinical study. In a press release, the NIH has confirmed that a Phase I clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers has begun.
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Prime Editing Expands the “Genetic Toolbox”
Scientists report the latest prime editing technology, prime editing, expands the “genetic toolbox” for more precisely creating disease models and correcting genetic problems.
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Electronic Deterrents Could Help Reduce Shark Bites
New technology suggests that using electronic deterrents could be a valid approach to reducing the incidence of shark bites.
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Treatment Shows Promise at Restoring Ovarian Function During Early Menopause
In a new study, a novel approach of administering platelet-rich plasma and gonadotropins near the ovarian follicles has shown promise in restoring ovarian function in women with early menopause.
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Drug Shown To Regenerate Lost Teeth Using Mouse Model
Tooth loss is a widespread problem in adults. Researchers have now shown in animal studies, that suppressing the gene USAG-1 using an antibody can efficiently stimulate tooth growth.
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Diabetes Drug Exploits Vulnerability in HIV
A team has uncovered an important vulnerability in HIV and has shown in preclinical experiments that metformin, a drug used to treat diabetes, seems able to exploit this vulnerability.
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Generating Proteins Using AI To Speed Up Drug Development
Researchers have used artificial intelligence to generate novel, functionally active proteins. The future applications could include the faster and more cost-efficient development of protein-based drugs.
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Metformin Reduces Seizure Frequency and Tumor Size in Tuberous Sclerosis
A team of researchers has found that metformin, a drug used to treat Type 2 diabetes, can reduce symptoms associated with tuberous sclerosis complex (TSC), including reducing the frequency of seizures and the size of tumors.
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HIV Vaccine Candidate’s Mechanism Revealed 20 Years Later
About two decades after first devising a new kind of vaccine, Oregon Health & Science University researchers are unlocking why it stops and ultimately clears the monkey form of HIV, called SIV, in about half of nonhuman primates – and why it’s a promising candidate to stop HIV in people.
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