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Unexpected Binding Between SARS-CoV-2 and Antiviral Drug
Researchers used neutron scattering to investigate interactions between telaprevir, a drug used to treat hepatitis C infection, and the SARS-CoV-2 main protease.
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High Vitamin D Levels May Protect Against COVID-19
New research has found that when it comes to COVID-19, having vitamin D levels above those traditionally considered sufficient may lower the risk of infection, especially for Black people.
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Viagra May Prolong the Life of Men With Coronary Heart Disease
Men with stable coronary artery disease who are taking Viagra due to impotence, appear to live longer and have a lower risk of experiencing a new heart attack, according to a new study.
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Team Discovers a Detonating Fuse for Basal-Like Breast Cancer
Basal-like breast cancer requires the support of the YAP protein to stimulate the growth of cancer stem cells. Targeting YAP could be a potential treatment strategy against this type of cancer in the future.
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Ibuprofen Disrupts Key Protein Complex in Colorectal Cancer Cells
The mechanism behind the anti-tumor properties of NSAIDs has been largely attributed to the inhibition of cyclooxygenases, however, several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.
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Anti-Androgen Drugs May Disarm COVID-19 Spike Protein
Finding from a preclinical study suggest that anti-androgen therapies may help to disarm the coronavirus spike protein used to infect cells, by reducing androgen levels. Two receptors, ACE2 and TMPRSS2, are regulated by androgen and facilitate SARS-CoV-2's entry into host cells.
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Behavioral Effects of Alcohol May Be Caused by Breakdown Products Produced in the Brain
Researchers have demonstrated that alcohol metabolism can occur in the mouse brain, due to the presence of the enzyme aldehyde dehydrogenase 2 (ALDH2). They also demonstrated that expression of ALDH2 in the mouse cerebellum mediates behavioral effects related to alcohol intoxication. The paper was published in Nature Metabolism.
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The Secret to Precisely Turning Genes On and Off
In a recent study, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.
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Delivering Vaccines Directly to the Lungs
Researchers showed that they could induce a strong memory T cell response in the lungs of mice by giving them a vaccine modified to bind to a protein naturally present in mucus.
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Oxford–AstraZeneca Vaccine Not Associated With Overall Risk of Thromboembolic Events, Says EMA
The European Medicines Agency (EMA)'s Pharmacovigilance Risk Assessment Committee (PRAC) has shared a statement after concluding its review of the Oxford–AstraZeneca COVID-19 vaccine following reports of thromboembolic events occurring in a small number people.
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