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Anti-SARS-CoV-2 Drug Candidate Enters Phase 1 Trial in the US
An anti-SARS-CoV-2 drug candidate enters its Phase I clinical trial in the United States on March 15.
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Pancreatic Tumors Exploit Multiple Mechanisms To Avoid Starvation
Researchers have described how pancreatic cancer cells use an alternative method to find necessary nutrients, defying current therapies, to help them grow and spread.
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Leprosy Drug Exhibits Potent Antiviral Activities Against SARS-CoV-2
Clofazimine, a drug already approved to treat leprosy, has been shown to exhibit potent antiviral activities against SARS-CoV-2 and can prevent the exaggerated inflammatory response linked to severe disease.
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Targeting Disease-Causing Proteins for Destruction
Scientists have developed a way to harness a cell's own recycling machinery to destroy disease-causing proteins, a method that could enable novel therapeutic strategies.
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Immune Receptor Protein Could Offer Autoimmune Disease Treatment Target
Rheumatoid arthritis is an autoimmune disease in which immune cells erroneously attack the body's own joint components and proteins, causing painful inflammation and even the destruction of bone. Scientists have now taken a step toward understanding and, potentially, treating rheumatoid arthritis better, with the identification of genes that were overexpressed in various mouse models of arthritis.
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Solving Nucleic Acid Synthesis Mystery May Help To Design New Antivirals
Scientists have solved the mystery of how living organisms distinguish RNA and DNA building blocks during gene expression, paving the way for the design of new antiviral drugs.
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Guided “Nanomissiles” Deliver Drugs Directly to the Tumor
Researchers have developed hybrid nanostructured particles that can be magnetically guided towards a tumor. They can also be tracked by their fluorescence and triggered to release the drug on demand using ultrasound.
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Shrinking Pancreatic Tumors by Starving Their Cellular “Neighbors”
Scientists have shown that by blocking "cell drinking", or macropinocytosis, in the tissue surrounding a pancreatic tumor, it is possible to slow the tumor's growth. This suggests that macropinocytosis could be exploited therapeutically.
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"Giraffe-Type" Gene-Edited Mice Are Resistant to High Blood Pressure
A new study has found that, when inserted into mice, giraffe genes confer resistance to high blood pressure.
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Finding New Uses for Existing Drugs
Researchers have uncovered potential novel therapeutic strategies for oral and esophageal carcinomas. The researchers found that combining two drugs, pitavastatin and capmatinib, inhibited the viability of oral cancer cells in culture, as well as the growth of tumors in a mouse model.
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