News

A study has revealed how T cells in the small intestine respond to bile acids, offering localized treatment direction for a cause of chronic illness.

A clinical trial is underway to determine whether people who are highly allergic or have a mast cell disorder are at increased risk for an immediate, systemic allergic reaction to the Moderna or Pfizer-BioNTech COVID-19 vaccines.

The UK rollout of the Moderna COVID-19 vaccine – known as mRNA-1273 – has commenced today in Carmarthen, Wales. mRNA-1273 is the third COVID-19 vaccine to be authorized for human use in the UK. It joins Oxford–AstraZeneca's ChAdOx1 vaccine and Pfizer–BioNTech's BNT162b2 vaccine as part of the country's large-scale vaccination program.

Scientists are aiming to validate an innovative radiotherapy as part of a safe, more effective and potentially less costly treatment for bladder cancer.

Lab-engineered antibodies remain the core facilitator of immunotherapies and CAR T-cell therapies. But these therapies have proved less effective against solid tumors, compared with other cancers. Now, researchers have uncovered why some of these antibody approaches appear to effectively kill cancer tumors in laboratory tests but are ineffective in clinical trials.

Researchers have discovered two new ways to induce tumor cell death which must both be triggered simultaneously by drugs to kill the majority of the tumor mass.

Researchers from the University of Nebraska Medical Center (UNMC) and the Department of Energy’s (DOE’s) Oak Ridge National Laboratory (ORNL) have now observed the complete atomic structure of an enzyme called manganese superoxide dismutaseMnSOD, including its proton arrangements, with neutron scattering.

Researchers have uncovered the structure of Glycine Transporter 1, it enables the uptake of glycine into neurons and acts as a neurotransmitter in the brain. This new information could open new avenues for developing therapeutics for psychiatric disorders.

The lab mouse has been sidelined for mental illness insight, as its rodent mind is considered too different from that of humans. A new study, however, shows there are important links between human and mouse minds in how they function and malfunction. Researchers have devised an approach to study how hallucinations are produced in the brain, providing a promising entry point to the development of new therapies for schizophrenia.

Scientists have developed a novel type of implantable sensor that can be embedded into an artificial polymeric tissue. The sensor is based on color-stable gold nanoparticles that are modified with receptors for specific molecules. The nanogold is implanted under the skin where it reports changes in drug concentrations by changing its color.