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Behavioral Effects of Alcohol May Be Caused by Breakdown Products Produced in the Brain
Researchers have demonstrated that alcohol metabolism can occur in the mouse brain, due to the presence of the enzyme aldehyde dehydrogenase 2 (ALDH2). They also demonstrated that expression of ALDH2 in the mouse cerebellum mediates behavioral effects related to alcohol intoxication. The paper was published in Nature Metabolism.
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The Secret to Precisely Turning Genes On and Off
In a recent study, scientists have shown how to simultaneously harness multiple forms of regulation in living cells to strictly control gene expression and open new avenues for improved biotechnologies.
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Delivering Vaccines Directly to the Lungs
Researchers showed that they could induce a strong memory T cell response in the lungs of mice by giving them a vaccine modified to bind to a protein naturally present in mucus.
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Oxford–AstraZeneca Vaccine Not Associated With Overall Risk of Thromboembolic Events, Says EMA
The European Medicines Agency (EMA)'s Pharmacovigilance Risk Assessment Committee (PRAC) has shared a statement after concluding its review of the Oxford–AstraZeneca COVID-19 vaccine following reports of thromboembolic events occurring in a small number people.
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New Study Provides Global Analysis of COVID-19 Vaccines
A new study has compared twelve COVID-19 vaccines that had initiated or announced the Phase III clinical trial stage by early November 2020. The study highlights the early successes, as well as the hurdles and barriers yet to be overcome for ending the global COVID-19 pandemic.
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This Nicotinic Acetylcholine Receptor Is Ready for Its Close-Up
UT Southwestern researchers have identified the structure of a key member of a family of proteins called nicotinic acetylcholine receptors in three different shapes.
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Anti-SARS-CoV-2 Drug Candidate Enters Phase 1 Trial in the US
An anti-SARS-CoV-2 drug candidate enters its Phase I clinical trial in the United States on March 15.
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Pancreatic Tumors Exploit Multiple Mechanisms To Avoid Starvation
Researchers have described how pancreatic cancer cells use an alternative method to find necessary nutrients, defying current therapies, to help them grow and spread.
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Leprosy Drug Exhibits Potent Antiviral Activities Against SARS-CoV-2
Clofazimine, a drug already approved to treat leprosy, has been shown to exhibit potent antiviral activities against SARS-CoV-2 and can prevent the exaggerated inflammatory response linked to severe disease.
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Targeting Disease-Causing Proteins for Destruction
Scientists have developed a way to harness a cell's own recycling machinery to destroy disease-causing proteins, a method that could enable novel therapeutic strategies.
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