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Light-Triggered Drug Delivery
A research team has developed a drug delivery system that allows nanoparticles to convert skin-penetrating near-infrared light into visible light so that drug release can be controlled in medical devices installed in the body.
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Taking a Closer Look at Microbial Friends and Foes With Intestine-on-a-Chip
Researchers have harnessed Wyss’s microfluidic Organ Chip technology to model the different anatomical sections of the mouse intestine and their symbiosis with a complex living microbiome in vitro. The researchers recapitulated the destructive effects of S. typhimurium on the intestinal epithelial surface in an engineered mouse Colon Chip.
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Quickly Calculating Drug–Target Binding Affinity With Machine Learning
The new technique, DeepBAR, quickly calculates the binding affinities between drug candidates and their targets.
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Novavax Announces COVID-19 Vaccine Has High Efficacy Against SARS-CoV-2 and Variant Strains
The biotechnology company Novavax has announced that its COVID-19 vaccine NVX-CoV2373 has a final efficacy of 96.4% against mild, moderate and severe disease.
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Computation Paves the Way for Cleaner Water
A research group has developed an algorithm to minimize or maximize the affinity of a given solute to the surface. The findings of the research show that computational methods can contribute in significant ways to next-generation membrane systems for sustainable water treatment.
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Cancer Cells Go Dormant To Dodge Chemotherapy
A new study suggests that cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, shielding them from aggressive treatments designed to destroy them.
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Molecule Halts Tumor Growth in Neuroblastomas
Researchers have discovered a signaling molecule, produced by Schwann cells, that can halt the uncontrolled growth of tumors in malignant and benign neuroblastomas.
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Highly-Selective Tool Developed To Study "Undruggable" Proteins
Scientists have developed a new highly-selective tool to study “undruggable” proteins, that works by analyzing the sugars they depend on.
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Compound From Chinese Herb Exhibits Reversible Male Contraceptive Effects
Triptonide, a natural compound purified from the vine plant Tripterygium wilfordii Hook F, has been shown to possess reversible contraceptive effects in male mouse and primate models. The findings were published in Nature Communications.
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A Microdosing High is Mostly a Placebo Effect, Psychedelic Study Suggests
A new study has found that participants who took placebos often reported the same beneficial effects as those that actually microdosed psychedelic substances. Likewise, those who believed they had taken a placebo, when they had taken a psychedelic drug, experienced fewer improvements to their wellbeing.
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