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Some Humans Carry DNA From an Archaic, Unknown Ancestor
A new analysis of ancient genomes suggests that different branches of the human family tree interbred multiple times, and that some humans carry DNA from an archaic, unknown ancestor.
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Recreating Nature: Chemists Create Synthetic Version of Natural Anti-Cancer Agent
Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.
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Deep Learning Algorithm Mines the Genome for Therapeutic Targets
A team of researchers have developed an algorithm through machine learning that helps predict sites of DNA methylation – a process that can change the activity of DNA without changing its overall structure – and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.
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Breaking Down a Common Computing Problem
Researchers have developed a new algorithm for solving a common class of problem -- known as linear inverse problems -- by breaking them down into smaller tasks, each of which can be solved in parallel on standard computers.
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Discovering the Strategies Tumor Cells Use To Evade Immune Attack
A new study has uncovered the strategies tumor cells use to evade immune system attack. The method developed for this work contributes to a better understanding of the "arms race" between immune defense and disease.
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Existing Alcoholism Drug Potentially Effective Against COVID-19
Chemists have used molecular modeling to identify two existing drugs that could be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer.
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New Anti-Alzheimer's Compound Reverses Memory Decline in Mice
A drug candidate previously shown to slow aging in brain cells has successfully reversed memory loss in a mouse model of inherited Alzheimer’s disease.
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Two Is Better Than One for Novel COVID-19 Mouse Model
Researchers have developed a new mouse model to study SARS-CoV-2 infection and disease and to accelerate testing of novel treatments and vaccines against the novel coronavirus.
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"Floppy" Proteins Used To Create Artificial Organelles Within Human Cells
Biomedical engineers have developed a method for controlling the phase separation of an emerging class of proteins to create artificial membrane-less organelles within human cells.
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Accelerating Progress in Preventing Resistance to Anticancer Drugs
Researchers have developed new models to study the molecular characteristics of lung and pancreatic tumors that are driven by mutations in the NTRK1 gene.
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