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Blocking Cholesterol Storage Could Halt Pancreatic Tumor Growth
Scientists have discovered that they can halt the growth of pancreatic cancer cells by interfering with the way the cells store cholesterol.
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Artificial Genes Sense Cellular Responses to Drugs
BUSM researchers have developed and implemented a new way to better understand how human cells communicate with each other, how this communication is disrupted in human diseases and how this can be corrected pharmacologically.
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Modified Form of Vitamin K Shows Promise Against Drug-resistant Epilepsy
A team of researchers has reported that a new vitamin K-based drug has proved effective in mouse models of medication-resistant seizures.
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Team Synthesizes Safer Nonaddictive Analgesics
A team has discovered a new class of drugs, capable of relieving pain and reducing fever without the danger of addiction or damage to the liver or kidneys.
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How Microorganisms Make Natural Drug Products
The active ingredients of many drugs are natural products. Similar to the production line in a factory, large enzyme complexes put these active agent molecules together inside microorganisms. A team of researchers has now succeeded in investigating the basic mechanisms of one of these "factories".
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Compounds Target Key Enzyme Halting SARS-CoV-2 Replication
Researchers have identified several existing compounds that block replication of the COVID-19 virus (SARS-CoV-2) within human cells grown in the laboratory.
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How Uromodulin Helps Against Urinary Tract Infections
The exact process by which uromodulin prevents inflammation had never been understood. Now an interdisciplinary team, drawn from three research groups at ETH Zurich together with researchers from the University of Zurich and the Children's Hospital Zurich, has filled this knowledge gap.
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Accelerated Discovery of Bioactive Components in Seaweed
Using state-of-the-art approaches coupled with bio- and cheminformatics and machine learning, researchers at the GEOMAR Helmholtz Centre for Ocean Research Kiel have succeeded in discovering new, bioactive components of the Baltic Sea seaweed Fucus vesiculosus and its fungal symbiont against infectious bacteria or skin cancer.
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Patients Exposed to Hormone-disrupting Chemicals in Some Medical Supplies and Medication
Health care providers may unintentionally expose patients to endocrine-disrupting chemicals by prescribing certain medications and using medical supplies.
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Hydroxychloroquine and Lopinavir/Ritonavir Treatment Arms for COVID-19 Discontinued
The World Health Organization (WHO) has accepted the recommendation from the Solidarity Trial’s International Steering Committee to discontinue hydroxychloroquine and lopinavir/ritonavir study arms.
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