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Novel Drug Target for Myelodysplastic Syndrome Discovered
A research group has analyzed the pathophysiology of myelodysplastic syndrome (MDS), a blood cancer that presents often in the elderly, and found the presence of the transcription factor RUNX3. Additional preclinical analyses of human MDS cells found an abnormal gene expression mechanism linked to the initiation and propagation of MDS stem cells and confirmed RUNX3 as a new therapeutic target.
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Repurposing Enzymatic Reactions To Aid Drug Production
A team has developed an environmentally efficient process for compound synthesis which could have potential applications in the pharmaceutical industry to aid drug production.
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Researcher Develops “Fat Burning” Molecule
Researchers have identified a “fat burning” molecule that decreased the body fat mass of mice without affecting food intake and muscle mass or increasing body temperature.
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Inhibiting Slug Protein Stops Spread of Pancreatic Cancer
Researchers from the Sanford Burnham Prebys Medical Discovery Institute have discovered that pancreatic cancer metastasis can be suppressed by inhibiting a protein called Slug that regulates cell movement
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Study Points to Potential New Treatment for Pancreatic Cancer
A new study looks at a combination treatment that could help patients with pancreatic cancer.
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When Cancer Cells Can’t Produce Their Own Fat, They Import More of It
When cancer cells are unable to make their own lipids, they import them from their environment to ensure a steady supply of these essential building blocks. This switch in fat metabolism from production to import could be exploited for cancer treatment.
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Making Vaccines Safe in All Temperatures
Scientists have now found a way to prevent warmed-up vaccines from degrading. By encasing protein molecules in a silica shell, the structure remains intact even when heated to 100°C, or stored at room temperature for up to three years.
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Innovation Enables Mass Production of Standardized Organoids
A recent innovation has enabled mass production of standardized organoids, paving the way for industrial use.
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3D Facial Scans To Speed Diagnoses for Rare Genetic Diseases
An international team has developed a prototype tool based on three-dimensional (3D) facial imaging that could make it easier for clinicians to diagnose genetic syndromes.
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Blocking BTK Protein Could Provide Clinical Benefit to Some With Severe COVID-19
Early clinical study findings suggest that blocking the Bruton tyrosine kinase (BTK) protein could provide clinical benefit to a small number of patients with severe COVID-19. The off-label use of the cancer drug acalabrutinib (a BTK inhibitor) was associated with reduced respiratory distress and a reduction in the overactive immune response in most of the treated patients.
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