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A Small Twist in Protein Structure Leads to a Big Reaction
Researchers devised a way to modify amide bonds with a twist to their chemical structure that significantly speeds up reactions.
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Blocking Tumor Signaling To Suppress the Spread of Melanoma
A team of researchers has suppressed the spread of melanoma to the lungs in a mouse model using an inhibitor of an enzyme called p38α kinase.
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New Molecule Stops Drug Cravings in Mice
A team from Duke University has developed a synthetic molecule that selectively dampens the physiological rewards of cocaine in mice. This molecule could represent a new class of drugs that may be more specific that currently available medications, with fewer adverse effects.
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Marine Molecules With Therapeutic Potential Against Alzheimer's Disease
A study has discovered two potential candidates to treat Alzheimer’s disease. The two marine molecules, meridianine and lignarenone B, can alter the activity of GSK3B activity, a protein linked to several neurodegenerative diseases.
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Immune Disease Model Points to Treatment for COVID-19 Cytokine Storms
Researchers have developed a transgenic mouse to model the deadly childhood immune disease hemophagocytic lymphohistiocytosis, they hope that this model could aid development of a treatment for COVID-related cytokine storms
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Antibodies Can Be Made Rapidly in Chicken Cells
Scientists have developed a system that can generate human antibodies against various antigens faster than existing methods.
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Which Drugs Are Being Used To Treat COVID-19?
With doctors and researchers around the world searching for effective treatments for COVID-19, many drugs approved to treat other diseases are being used in hopes that they’ll be effective against the virus. Researchers have cataloged every use documented in medical literature so far.
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Team Inhibits Molecule in Myeloid Cells To Shrink Tumors
Inhibiting a molecule hijacked by tumor cells to suppress the immune system shrank tumors in cell and mouse models.
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Compounds Pave Way to Possible Type 1 Diabetes Treatment
Researchers have identified two classes of compounds that prevent most of the effects of interferon-α (IFNα) on human beta cells, paving the way for potential future clinical trials of treatments for Type 1 diabetes (T1D).
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Trial Investigates Remdesivir–Baricitinib Combo as COVID-19 Treatment
Following on from remdesivir’s promising results from previous studies, a new trial is now investigating remdesivir in combination with baricitinib or placebo as a treatment for COVID-19, in a double-blind, randomized trial.
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