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Team Reveal Key to the Survival of Dormant Breast Cancer Cells
A common anti-diabetes drug being tested in several clinical trials as an anti-cancer agent was shown to activate fat metabolism that promoted the survival of dormant breast cancer cells, in a recent study, suggesting that the drug has context-dependent effects on cancer cells.
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AI-driven Drug Discovery Strategies To Fight COVID-19
A large collaborative effort combines artificial intelligence with physics-based drug docking and molecular dynamics simulations to rapidly hone in on the most promising molecules to test in the lab, in the search for a therapeutic strategy against COVID-19.
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Novel Compounds Designed To Inhibit SARS-CoV-2 Main Protease
A team of Chinese scientists has recently developed two novel compounds that inhibit the SARS-CoV-2 main protease (Mpro) and one of them appears to be a good drug candidate for further clinical studies.
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Glaucoma Could Be Successfully Treated With Gene Therapy
A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients.
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Targeting the Immune System To Treat OCD
Why are patients with autoimmune diseases more susceptible to mental health disorders? How does the immune system contribute to brain function, and how can this go "wrong"? These questions have been pondered by a group of scientists who reduced anxiety in a mouse model by targeting the immune system.
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NIH Treatment Guidelines Created for COVID-19
A panel of U.S. physicians, statisticians, and other experts has developed treatment guidelines for coronavirus disease 2019 (COVID-19). The guidelines will be updated as new data are published in peer-reviewed scientific literature and other authoritative information emerges.
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Age-related DNA Modifications Linked to Eye Disease Susceptibility
Researchers profiling epigenomic changes in light-sensing mouse photoreceptors have found that age-related changes in gene expression regulation may be linked to eye disease susceptibility.
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UK Human Clinical Trials of COVID-19 Vaccine Set To Begin
Researchers at University Hospital Southampton (UHS) and the University of Southampton are set to begin trials of a vaccine pioneered in the UK which could protect against COVID-19.
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Key Mechanism Enables Cancer Cells To Evade the Immune System
Researchers uncover a key mechanism that regulates PD-L1, a protein that helps cancerous cells evade detection by the immune system and is the target of several immunotherapy drugs
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Potential Drug Treatments for Telomere Diseases Discovered
A new study points to a potential therapeutic strategy for dyskeratosis congenita and other telomere diseases, in which cells age prematurely. Using cells donated by patients with the disease, researchers have identified several small molecules that appear to reverse the cellular aging process.
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