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Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome.

Novel vaccine delivery technology will contribute to efforts to develop universal vaccines and improve global immunization capabilities essential for combating coronavirus, reports the Journal of Investigative Dermatology .

As drugs more precisely target cancer subtypes, clinical studies designed to test these drugs are enrolling fewer patients. Smaller studies reduce the likelihood of uncovering rare side effects, and so it may fall on clinicians using these drugs after FDA approval to notice medication side effects that went undetected during clinical trials.

A common anti-diabetes drug being tested in several clinical trials as an anti-cancer agent was shown to activate fat metabolism that promoted the survival of dormant breast cancer cells, in a recent study, suggesting that the drug has context-dependent effects on cancer cells.

A large collaborative effort combines artificial intelligence with physics-based drug docking and molecular dynamics simulations to rapidly hone in on the most promising molecules to test in the lab, in the search for a therapeutic strategy against COVID-19.

A team of Chinese scientists has recently developed two novel compounds that inhibit the SARS-CoV-2 main protease (Mpro) and one of them appears to be a good drug candidate for further clinical studies.

A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients.

Why are patients with autoimmune diseases more susceptible to mental health disorders? How does the immune system contribute to brain function, and how can this go "wrong"? These questions have been pondered by a group of scientists who reduced anxiety in a mouse model by targeting the immune system.

A panel of U.S. physicians, statisticians, and other experts has developed treatment guidelines for coronavirus disease 2019 (COVID-19). The guidelines will be updated as new data are published in peer-reviewed scientific literature and other authoritative information emerges.

Researchers profiling epigenomic changes in light-sensing mouse photoreceptors have found that age-related changes in gene expression regulation may be linked to eye disease susceptibility.