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Century-long Puzzle (Dis)solved About Protein Crystals in Asthma
Charcot-Leyden Crystals are made from the protein Galectin-10 and were discovered in the airways of asthmatics as early as 1853. However, the crystals have been largely ignored by scientists, and their actual link to disease remained unknown, until now.
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Are Transplanted Stem Cells Healing the Target Organ? Perhaps Ask the Exosomes
While many regenerative medicine applications are being pursued, the ability to track cells after transplant and determine their therapeutic efficacy is a challenge. Could exosomes, circulating cell-derived vesicles, hold the key?
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Mitochondria-Nucleus Interactions Could Have Implications for Mitochondria Replacement Therapy
Mitochondria, the "batteries" that produce our energy, interact with the cell’s nucleus in subtle ways previously unseen in humans, according to research published today in the journal Science.
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Uncovering the Function of Liver Cancer Genes in Mini-organs
Scientists have developed a human model in which they use organoids, or mini organs, to study the function of specific genes that are mutated in liver cancer.
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Gene Linked to Impaired Memory in Down Syndrome – A Potential Drug Target?
It may one day be possible to reverse abnormal embryonic brain development linked to Down syndrome (DS) and improve cognitive function by therapeutically targeting a key gene known as OLIG2 prenatally, suggests newly published findings.
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A Possible Reason Why Some Drugs Are Ineffective in Colorectal Cancer
A certain group of cancer drugs (MEK Inhibitors) activate the cancer-promoting Wnt signaling pathway in colorectal cancer cells. The findings suggest a possible explanation for why these drugs are not effective in colorectal cancer.
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Superefficient Data-storage Devices Could Power Future Computers
Researchers have achieved material magnetization switching on the shortest timescales, at a minimal energy cost, thus creating a prototype of energy-efficient data storage devices.
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Molecule Found in Red Wine Lowers Blood Pressure
A recent study published in the journal Circulation shows that a molecule found in red wine causes a drop in blood pressure, which could help scientists combat heart and circulatory diseases.
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Octopus "Suckers" Inspire New Wearable Sensors
Octopus “suckers" are the inspiration for the development of a new graphene-based adhesive biosensor that could prove more robust than previous technology.
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FDA-approved Drugs Reverse Aging in Nematodes
Researchers collaborated to derive a transcriptomic signature of aging, which they confirmed using large transcriptomic databases. They discovered that aging in nematodes is partially programmed and can be therapeutically reversed by a number of FDA-approved drugs.
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