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Cracking a One-Two Punch Against Melanoma
Updated, safer versions of diphtheria fusion toxin DAB-IL-2 show promise in reducing tumor growth.
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Blueprint Guides Treatment of Deadly Brain Tumor
In a study of mice and human brain tumors researchers searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients’ tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation.
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New Machine Learning Method Could Prevent Unnecessary Breast Surgery
Researchers have found a machine learning method that can predict the likelihood that a high-risk type of breast lesion is cancerous, potentially saving some women from unnecessary surgeries and overtreatment.
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Lung Therapy Targets Derived From Fetal Signaling Pathways
Specialized lung cells appear in the developing fetus much earlier than scientists previously thought.
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Can We Trust Scientific Discoveries Made Using Machine Learning?
Rice University statistician Genevera Allen says scientists must keep questioning the accuracy and reproducibility of scientific discoveries made by machine-learning techniques until researchers develop new computational systems that can critique themselves.
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3D Protein Structure Aids Anti-cancer Drug Design
A research team has discovered a new mechanism for a class of anti-cancer drugs known as E1 inhibitors. Their findings reveal a novel binding site that will promote drug design of more efficient E1 inhibitors.
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Sparing Sensitive Organs from Radiation Damage to Reduce Side Effects
A new way to plan radiotherapy could help shape treatment away from sensitive organs near tumors to reduce side-effects, a new study shows.
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Light-based Production of Drug Discovery Molecules
EPFL chemists have developed a light-based chemical method for cheap and simple production of chemical molecules used in drug discovery, such as muscle relaxants and antimicrobials.
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Measuring the "Games" Cancer Cells Play
Researchers develop a first-in-class “game assay” which they used to directly quantify and describe the eco-evolutionary interactions between sensitive and resistant tumor cells in an experimental model of non-small cell lung cancer cells sensitive to targeted therapy.
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Therapy Combo Promising in Small Cell Lung Cancer Model
A combination of immune checkpoint blockade and targeted therapies that block normal DNA damage repair achieved significant tumor regression in mouse models of small cell lung cancer, suggesting a promising new approach for treating patients with this aggressive cancer.
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