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Exosomes are Fundamental to COPD Pathogenesis
Researchers have found a novel, previously unreported pathogenic entity that is a fundamental link between chronic inflammation and tissue destruction in the lungs of patients with chronic obstructive pulmonary disease.
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Osteoarthritis Stem Cell Therapy Success in Phase I and II Trials
Details of a new therapy for the symptomatic treatment of osteoarthritis have been revealed, using mesenchymal cells from umbilical cord stroma.
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Millions on Prescription Sleeping Pills Would Sleep Through a Fire Alarm
In a trial of one of the main class of prescription sleeping pills, half the participants slept through a fire alarm as loud as someone vacuuming next to their bed. But a newer alternative preserves the ability to wake in response to danger signals, according to a new research.
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VISTA Checkpoint a Potential Pancreatic Cancer Immunotherapy Target
A new potential immunotherapy target has been identified for pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.
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Machine Learning Uncovers New Insights into the Human Brain
Researchers have successfully employed machine learning to uncover new insights into the cellular architecture of the human brain. The team demonstrated an approach that automatically estimates parameters of the brain using data collected from fMRI, enabling neuroscientists to infer the cellular properties of different brain regions without probing the brain using surgical means.
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Liver-on-chip Enables Real-time Cholesterol Measurement
A microfluidic liver-on-chip system which enables real-time measurement of cholesterol has been developed to study the effects of potentially cholesterol-lowering drugs in real time.
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How Drugs Can Minimize Side Effects of Chemo
Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects.
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Predicting Anti-Diabetes Drug Response Using Fat Cell Genetics
In a new study published in Cell Stem Cell, a team of researchers have demonstrated, using fat cells derived from human stem cells, that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.
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Drug Suppresses Formation of Metastases
The most deadly aspect of breast cancer is metastasis. It spreads cancer cells throughout the body. Researchers have now discovered a substance that suppresses the formation of metastases.
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Pregnancy-associated Malaria Vaccine Candidate Passes First Test
A vaccine against fatal pregnancy malaria shows promising results in the first tests in humans.
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