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Circadian Rhythms Impact Drug Effectiveness

Using tiny, engineered livers derived from human patients, researchers found that more than 300 liver genes are under circadian control. These circadian variations affect how much of a drug is available and how effectively the body can break it down.
A close up of a patients hand attached to a tube feeding medicine.
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New Closed-Loop Drug Delivery System Could Improve Chemotherapy

To make chemotherapy dosing more accurate, MIT engineers have come up with a way to continuously measure how much drug is in the patient’s system during the hours-long infusion.
Neurons degenerating.
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164 Active Trials Are Testing Alzheimer’s Therapeutics

Alzheimer’s treatment studies offer hope as UNLV expert predicts new potential drugs, biomarkers will yield critical insight for future development.
A ginger haired woman leaning over the arm of a chair.
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Scientists Identify Brain Circuit That Suppresses Appetite During Nausea

Researchers at the Max Planck Institute for Biological Intelligence now identified the circuit in the brain that prevents mice from eating when they feel nauseous.
Immunotherapy attacking a cancer cell.
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Immunotherapy Combination Approved for Non-Muscle Invasive Bladder Cancer

FDA approves immunotherapy drug combo for non-muscle invasive bladder cancer after UCLA-led research shows improved outcomes for patients.
Two white mushrooms.
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Psilocybin Shows Promise for Treatment-Resistant Depression – But Is It Safe?

Commonly referred to as “magic mushrooms,” psilocybin is a promising alternative treatment for people with medication-resistant depression and anxiety.
A baby laying down.
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No Adverse Health Risks From Steroids Used for Pre-Term Birth, Study Finds

A new study has found there are no adverse long-term cardiovascular health consequences for the now-adult children of mothers who were given corticosteroids.
Microscopic image of a group of bacteria cells
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Phage Therapies for Multidrug-Resistant Infections Should Consider Host Response

Research has found that therapeutic phages can be detected by epithelial cells of the human respiratory tract and elicit an immune response. These findings suggest that human–host interactions should be a key factor when designing phage therapies.
A blue beetle.
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First Use of CRISPR-Cas9 Gene Editing in Kissing Bugs

Genetic technologies like CRISPR have become an integral tool for strategies to control infectious diseases spread by living organisms like kissing bugs.
Protein structures.
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Scientists Uncover the Cellular Functions of Proteins Integral to Inflammatory Diseases

Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.
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