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Antibody Candidate for Ebola Treatment is Safe in Adults
The investigational Ebola treatment mAb114 is safe, well-tolerated, and easy to administer, according to findings from an early-stage clinical trial published in The Lancet.
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The Hitchhiker’s Guide to Defeating Glioblastoma
A new approach using multiple microRNA ‘hitchhikers’ to weaken cancer cells in advance of standard therapy shows promise in preclinical models.
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Kidney Injury Healing Powers for Resident Macrophages?
During development in the womb, immune cells called macrophages go to the kidneys, and they remain there for life. Understanding the possible healing role for these macrophages after kidney damage may be crucial to helping treat patients who suffer acute kidney injury.
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Temperature-stable Tuberculosis Vaccine Enters Clinical Testing
Vaccinations have begun in a Phase 1 human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis vaccine candidate.
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New Vaccine Offers Fresh Take On Malaria Fight
This new vaccine reduced the malaria-causing parasite’s release from the liver and into the blood of infected rhesus macaques by 75 to 80 percent at the Oregon National Primate Research Center at OHSU.
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Vocabulary of Immune Cells Extended by Protein Engineering
Researchers around the world are on the search for new therapies – so far in vain. An interdisciplinary team from the fields of structural biology, immunology and cell biology has now, for the first time, successfully produced a protein that could balance the overshooting immune response.
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Key Signaling Protein Linked to Aggressive Cancers
Scientists have identified a protein which is associated with more aggressive breast, colorectal and ovarian cancers, which could be used to assist the diagnosis and development treatments for these cancers.
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Tick-tock: Drug Could Stop Cancer Cells’ Biological Clock
Scientists find and test a promising drug that stops cancer by interfering with the cancer cells’ metabolism and other circadian-related functions.
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Making Resistant Melanomas Susceptible to Immunotherapy
A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies.
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Pre-symptomatic Skin Test for Prion Disease May Replace Brain Biopsy
Preclinical detection of prions has proven difficult, but new research suggests skin samples hold early signs of prion disease that precede neurologic symptoms.
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