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Death from heart failure in men and women compared in a study of over 90 000 patients

Researchers have successfully prevented the development of a fatal neurodegenerative disorder, Gaucher disease, using fetal gene therapy, in mice. The study highlights the potential of using this approach to combat lethal neurodegenerative diseases affecting newborns.

Spicy foods elicit a pungent or hot and painful sensation that repels most mammals. However, the tree shrew, a species closely related to primates, seems to violate this rule of thumb.

A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions.

There is currently no treatment for curing osteoarthritis, which affects 80% of the population over 75 years of age. But researchers who have been studying the problem have come up with a new treatment that delivers previously-identified active principles directly into the joint in the form of nanocrystals inserted into microparticles.

New research that used a machine-learning algorithm to investigate MRI images of schizophrenia patients has successfully identified response to antipsychotic treatment in 4 out of 5 patients.

Researchers describe the central role played by an enzyme called phosphatidylinositol 3-kinase gamma (PI3Kγ) in regulating the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.

Research in mice shows that a pharmacological strategy can alleviate multiple behavioral and cellular deficiencies in a mouse model of fragile X syndrome (FXS), the most common inherited form of intellectual disability and a major single-gene cause of autism spectrum disorders.

A mouse study that made over 100,000 measurements of body weight and fat has concluded that the sole driver of obesity in mice is increased dietary fat content.

Many cancer patients suffer from a loss of body mass known as cachexia. A new study shows that the hormone testosterone is effective at combatting cachexia in cancer patients and improving quality of life.