The Placebo Effect (and Dopamine) Can Affect Antidepressants' Efficacy
Levels of dopamine and the placebo effect can determine whether patients with social anxieties improve when treated with SSRIs. A new study shows the effect was four times higher for patients with high expectations of the medication compared with patients with low expectations.
Intestine Chip Created To Test Potential Treatments for COVID-19
Scientists used a human Intestine Chip to study coronavirus infection and potential treatments in an environment that mimics the human intestine more effectively than cells grown in a dish.
Alzheimer’s Trial Will Test Two Drugs in Combination
The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) at Washington University School of Medicine in St. Louis has announced that it will be targeting two key Alzheimer’s proteins – amyloid and tau – as part of its Tau Next Generation Alzheimer’s prevention trial.
Drug To Treat Eye Cancer Set To Begin Clinical Trials
A drug called MTI-201, designed to treat uveal melanoma, has been given approval to commence clinical phase testing.
How Do Antibiotics Get Into Gram Negative Bacteria?
Researchers have developed a new method to determine how antibiotics with specific chemical properties thread their way through tiny pores in the otherwise impenetrable cell envelopes of Gram negative bacteria.
Tool Assesses Protein Secretability on Proteome-Wide Scale
Researchers have developed a methodology to investigate the secretability of several hundred thousand protein sequences at once. This new tool enables training of (deep) machine learning predictors of protein secretability and allows for studies on eukaryotic protein secretion.
Benefits of Genome Sequencing in Children With Cancer Revealed
According to research, unraveling the entire genetic code for each child who has been diagnosed with cancer can give a more accurate diagnosis or reveal new treatment options.
Coating Nanoparticles in Polymer Aids Drug Delivery to the Brain
Treating diseases such as Alzheimer’s or Parkinson’s is a challenge because drugs have to be able to cross the blood–brain barrier. To solve this issue, scientists are optimizing polymer-coated nanoparticles to increase their permeability across this barrier and consequently the delivery of encapsulated drugs in the brain.
Visible Light Provides a Sustainable Alternative in Drug Production
Researchers have discovered a new approach for using visible light to structurally modify bioactive molecules in chemical reactions, providing a possible sustainable method that could be used in the development of new medicines.
Protecting Macrophages From Overload Helps Inflammation Resolution
New data shows how inflammatory reactions can be resolved by "rewiring" the mitochondria of macrophages to alter metabolism and protect against overloading.