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Could Extracellular Vesicles be Personalized Drug Delivery Vehicles?
Creating enough nanovesicles to inexpensively serve as a drug delivery system may be as simple as putting the cells through a sieve, according to an international team of researchers who used mouse autologous — their own — immune cells to create large amounts of fillable nanovesicles to deliver drugs to tumors in mice.
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Living on the Edge: Supercomputing Powers Protein Analysis
Computing techniques, also used on social networks, can help scientists views the connections between our proteins. The technique visualizes proteins as 'nodes' and the connections between the proteins as 'edges'.
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Synthesis of Drug-Like Molecules Simplified Using New Cross-Coupling Method
Researchers have designed a new molecule-building method. The technique, described recently in the journal Science, paves the way toward other new chemical reactions and facilitates the synthesis of pharmaceutically-relevant molecules.
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CRISPR-Based System Identifies New Drug Targets in Aggressive Leukemia
Scientists have harnessed CRISPR, the gene-editing tool, to find highly specific dependencies in a deadly subtype of leukemia. They used an experimental drug to target these, halting cancer growth in cultured cells.
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Domainex Appoints Dr Bodo Spori as Head of Business Development for Europe
Domainex Ltd, a privately-owned drug discovery services company, is pleased to announce the appointment of Dr Bodo Spori as Head of Business Development for Europe.
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Combination Drug Trial Launched to Eradicate B-Cell Malignancies
Researchers at University of California San Diego School of Medicine, in collaboration with local biotechnology company Oncternal Therapeutics, have launched a phase Ib/II clinical trial to evaluate the combined effectiveness of a standard of care drug with a novel monoclonal antibody that target B-cell malignancies, which include leukemias and lymphomas.
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Blocking Amino Acid Found in Asparagus Stops Spread of Breast Cancer
Scientists have discovered that an amino acid called asparagine is essential for breast cancer spread, and by restricting it, cancer cells stopped invading other parts of the body in mouse models, according to research published in the journal Nature.
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Computer Model Describes the "Architecture of Life"
The study looks past the molecules inside cell, and focuses on their shape and a principle called "tensegrity".
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New Targeted Therapy Could Combat Drug Resistant Cancer Cells
A new targeted therapy that could combat drug resistance has been found to be safe in early trials, allowing it to move to the next stage of development.
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Fighting Sepsis: Drug ‘Revs Up’ the Immune System
Sepsis develops when an infection triggers an overwhelming immune response, ultimately wreaking havoc on the immune system. Now, a small clinical trial led by researchers at Washington University School of Medicine in St. Louis shows that a drug that revs up the immune system holds promise.
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