News

Researchers show that acute noxious heat sensing in mice depends on a triad of transient receptor potential (TRP) ion channels: TRPM3, TRPV1, and TRPA1.

Researchers report the one-step synthesis of a ketone from an aldehyde by the combination of thiazolium N-heterocyclic carbene and palladium/bisphosphine catalysts in one flask. The two catalysts function in a synergistic manner. This study is expected to lead to new synthesis processes of precursor compounds for medications.

Researchers find liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse.

MIT engineers have developed new technology that could be used to evaluate new drugs and detect possible side effects before the drugs are tested in humans. Using a microfluidic platform that connects engineered tissues from up to 10 organs, the researchers can accurately replicate human organ interactions for weeks at a time.

By applying analytical techniques often reserved for large-scale industrial bioreactors to smaller lab-based counterparts, researchers are bridging the gap between different ways of mixing biomaterials.

A new class of experimental drugs reduces hot flushes in menopausal women by almost three-quarters in just three days. The new analysis, published in the journal Menopause, also revealed sleep and concentration significantly improved in the three-day window.

Researchers from the University of Illinois at Chicago suggests that the drug oseltamivir - commonly known as Tamiflu - does not cause an increased risk of suicide in pediatric patients.

Researchers at A.C. Camargo Cancer Center in Brazil have found markers in the blood of head and neck cancer patients that can help identify cases that are likely to evolve to metastasis or develop local relapse after treatment.

A particular hydrogel, a self-assembling multidomain peptide (MDP) with the amino acid sequence K2(SL)6K2, is bioactive. Researchers found that even without additives their MDP is rapidly infiltrated by host cells, provokes a temporary inflammatory response, does not develop a fibrous capsule, supports the infiltration of a mature vascular network and recruits nerve fibers.

A University of Colorado Cancer Center study published today pinpoints a molecule that links autophagy and apoptosis, namely a transcription factor called FOXO3a. While researchers have known of the relationship between autophagy and apoptosis, what creates this link hasn’t been clear – in other words, we have known that turning off autophagy can help drugs push cancer cells into apoptosis, but we haven’t known how.