We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
A General and Facile One-Pot Process of Isothiocyanates from Amines under Aqueous Conditions
News

A General and Facile One-Pot Process of Isothiocyanates from Amines under Aqueous Conditions

A General and Facile One-Pot Process of Isothiocyanates from Amines under Aqueous Conditions
News

A General and Facile One-Pot Process of Isothiocyanates from Amines under Aqueous Conditions

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "A General and Facile One-Pot Process of Isothiocyanates from Amines under Aqueous Conditions"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Abstract
A general and facile one-pot protocol for the preparation of a broad range of alkyl and aryl isothiocyanates has been developed from their corresponding primary amines under aqueous conditions. This synthetic process involves an in situ generation of a dithiocarbamate salt from the amine substrate by reacting with CS(2) followed by elimination to form the isothiocyanate product with cyanuric acid as the desulfurylation reagent. The choice of solvent is of decisive importance for the successful formation of the dithiocarbamate salt particularly for highly electron-deficient substrates. This novel and economical method is suitable for scale-up activities.

The article is published online in Beilstein Journal of Organic Chemistry and is free to access.

Advertisement