Alcohol ADME in Primates Studied with Positron Emission Tomography

A microfluidic liver-on-chip system which enables real-time measurement of cholesterol has been developed to study the effects of potentially cholesterol-lowering drugs in real time.

Researchers at the University of Zurich have determined the three-dimensional structure of the receptor that causes nausea and vomiting as a result of cancer chemotherapy. The study explains for the first time why some drugs work particularly well in ameliorating these side effects.

In a new study published in Cell Stem Cell, a team of researchers have demonstrated, using fat cells derived from human stem cells, that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.