Anti-Aging Drug May Prevent Age-Related Declines in Proteostasis

Aging leads to the deterioration of protein quality control mechanisms in human cells, resulting in age-related problems. In a recent study, a research team from Korea tested the effects of the drug IU1 on proteasomes and autophagy, two important systems in proteostasis. Using fruit flies as an animal model, they found that IU1 can prevent age-related decline in proteostasis, paving the way for anti-aging therapies especially for degenerative diseases like Alzheimer’s.

Aging is an inevitable phenomenon and is accompanied by several comorbidities. To this end, research into the effects of aging has become paramount, and scientists are looking for ways to slow down aging and its detrimental impact on the human body. While aging ultimately causes deterioration in all body systems, the disruption of protein homeostasis or ‘proteostasis’ is one of the major underlying reasons.

Our cells have several mechanisms that help detect damaged or misfolded proteins and break them down. These ‘protein quality control’ systems prevent faulty proteins from aggregating and accumulating, causing cellular stress and long-lasting issues. As a person ages, these systems decline in function, which sets the stage for many age-related degenerative diseases and chronic conditions. Thus, preventing the disruption of proteostasis mechanisms could be the key to increasing longevity and improving the quality of life among older adults.

In this vein, a research team from Korea set out to investigate the relationship between two essential protein quality control systems, namely proteasomes and autophagy. The researchers led by Professor Seogang Hyun from Chung-Ang University, Korea, identified a drug that could preserve the performance of these systems, demonstrating interesting anti-aging effects. This study was made available online on August 15, 2024 in the journal Autophagy.

Proteasomes are protein complexes that break down faulty proteins into smaller peptides. On the other hand, autophagy is a process by which cells degrade and recycle larger structures, including protein aggregates, through the formation of specialized vesicles. Both systems work in concert to maintain proteostasis, but the mechanism of their synergistic activation to mitigate the effects of aging is not well understood.

Fortunately, an interesting compound ended up catching Prof. Hyun’s attention. “A few years ago, I learned from an academic conference that a certain drug called IU1 can enhance proteasomal activity, which encouraged our group to test its anti-aging effects,” he explains.

The researchers employed an animal model for studying the aging process: fruit flies from the genus Drosophila. Since fruit flies have a short lifespan and their age-related muscle deterioration is quite similar to that in humans, Drosophila constitutes a valuable model for studying aging. They treated flies with the drug IU1 and measured various behavioral- and proteostasis-related parameters. The results were quite promising, as Prof. Hyun remarks: “Inhibiting the activity of ubiquitin specific peptidase 14 (USP14), a component of the proteasome complex, with IU1 enhanced not only proteasome activity but also autophagy activity simultaneously. We demonstrated that this synergistic mechanism could improve age-related muscle weakness in fruit flies and extend their lifespan.” Worth noting that similar results were obtained in human cells.

These findings have important ramifications, especially regarding advances in anti-aging therapy. “Reduced protein homeostasis is a major characteristic of degenerative diseases such as Alzheimer's and Parkinson's disease. The results of our study might lay the groundwork for the development of treatments for various age-related diseases,” highlights Prof. Hyun.

We hope that these newfound insights pave the way for therapeutics that improve quality of life and extend lifespans.

Reference:

Lim JJ, Noh S, Kang W, Hyun B, Lee BH, Hyun S. Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner. Autophagy. 2024. doi: 10.1080/15548627.2024.2389607

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