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Ants Can Recognise Infected Wounds and Produce Antibiotics To Treat Them

A Matabele ant tends to the wound of a fellow ant whose legs were bitten off in a fight with termites.
Credit: Erik Frank / University of Wuerzburg.
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The Matabele ants (Megaponera analis), which are widespread south of the Sahara, have a narrow diet: They only eat termites. Their hunting expeditions are dangerous because termite soldiers defend their conspecifics – and use their powerful mandibles to do so. It is therefore common for the ants to be injured while hunting.

If the wounds become infected, there is a significant survival risk. However, Matabele ants have developed a sophisticated healthcare system: they can distinguish between non-infected and infected wounds and treat the latter efficiently with antibiotics they produce themselves. This is reported by a team led by Dr Erik Frank from Julius-Maximilians-Universität (JMU) Würzburg and Professor Laurent Keller from the University of Lausanne in the journal Nature Communications.

Treatment Drastically Reduces Mortality

"Chemical analyses in cooperation with JMU Professor Thomas Schmitt have shown that the hydrocarbon profile of the ant cuticle changes as a result of a wound infection," says Erik Frank. It is precisely this change that the ants are able to recognise and thus diagnose the infection status of injured nestmates.

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For treatment, they then apply antimicrobial compounds and proteins to the infected wounds. They take these antibiotics from the metapleural gland, which is located on the side of their thorax. Its secretion contains 112 components, half of which have an antimicrobial or wound-healing effect. And the therapy is highly effective: the mortality rate of infected individuals is reduced by 90 per cent, as the research group discovered.

Analysis of Ant Antibiotics is Planned

"With the exception of humans, I know of no other living creature that can carry out such sophisticated medical wound treatments," says Erik Frank. Laurent Keller also adds that these findings “have medical implications because the primary pathogen in ant’s wounds, Pseudomonas aeruginosa, is also a leading cause of infection in humans, with several strains being resistant to antibiotics”.

Are Matabele ants really unique in this respect? The Würzburg researcher now wants to explore wound care behaviours in other ant species and other social animals. He also wants to identify and analyse the antibiotics used by Matabele ants in cooperation with chemistry research groups. This may lead to the discovery of new antibiotics that could also be used in humans.


In this video a Matabele ant can be seen treating a wounded conspecific marked with a white dot. It grabs its metapleural gland with a front leg, collects antibiotic substances from there and transfers them to the wound.

Reference: Frank ErikT, Kesner L, Liberti J, et al. Targeted treatment of injured nestmates with antimicrobial compounds in an ant society. Nat Commun. 2023;14(1):8446. doi: 10.1038/s41467-023-43885-w

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