ASINEX and Dompe Announce Successful Collaboration
News May 29, 2007
DOMPE’ pha.r.ma SpA and ASINEX have announced a project which involved the synthesis and purification of a large targeted orientated library of small molecules using High Throughput Chemistry (HTC) methodology.
The realization of this project was made possible by the close collaboration of DOMPE’ Chemistry Department and ASINEX Computational Departments. A diverse virtual library was generated using a mixture of ASINEX proprietary building blocks and DOMPE’ proprietary synthons. Synthesis and compounds purification were carried out by ASINEX high throughput automated platform.
Dmitry Genis, ASINEX’s CEO said: “Having established an automated platform capable of running 8000 reactions per month and with an ability to purify in HT roughly 8-10K compounds, we can now further expand the broad range of our services including High Throughput Purification and the realization of fast and cost-effective combinatorial libraries on an exclusive basis. The excellent delivery rate indicates the quality and the effectiveness of the library design”.
Gaetano Clavenna, President of Dompé pha.r.ma, commented: The collaboration with ASINEX represents a key step forward in our research programs in the area of allosteric GPCR modulators that surely represents a primary focus for our group. The strong expertise of ASINEX in the field of combinatorial chemistry extraordinarily fits with Dompé pha.r.ma competences and we have great expectations for the results of this project.
Modified Form of Botox Could Replace Opioids as Treatment for Chronic PainNews
A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects and, in time, could replace opioid drugs as a safe and effective way of treating chronic pain, according to new research.READ MORE
Key Ingredient in Diabetes Drug Modified to Improve Side EffectsNews
Improved medications for Type 2 diabetes are one step closer thanks to a new discovery reported this week. By modifying the key ingredient in current diabetes drugs, the researchers produced a compound that was effective for hyperglycemia in animal trials, yet without the most problematic side effects of current drugs.READ MORE
Tackling Cancer at Ground Zero: Designer Molecule Inhibits Protein TargetNews
A new molecule designed by University of Adelaide researchers shows great promise for future treatment of many cancers. The new molecule successfully targets a protein that plays a major role in the growth of most cancers.READ MORE