Clanotech Receives Orphan Drug Designation in the U.S.
News Mar 28, 2015
Clanotech AB has announced that its candidate drug CLT-28643 has received orphan drug designation by the U.S. Food and Drug Administration (FDA) for prevention of scarring after glaucoma surgery.
The European Medicines Agency (EMA) has previously granted an orphan drug designation pertaining to the EU. The orphan drug designations will significantly shorten future market approval processes and reinforce market exclusivity for a launched product in the U.S. and EU.
“This positive decision from the FDA underpins the great need for products that can improve the outcome of glaucoma surgery. Clanotech is now preparing for a phase I/II trial with CLT-28643”, said Patrizia Caldirola, CEO, Clanotech.
Clanotech’s lead compound, an α5β1-integrin antagonist, has anti-angiogenic, anti-fibrotic and anti-inflammatory properties. Based on promising preclinical data in animal models for glaucoma, CLT-28643 has the potential to regulate wound healing processes following glaucoma surgery.
Glaucoma patients refractory to medications that lower the intraocular pressure undergo surgical intervention that creates a flap in the eye to drain liquid and more effectively lower the pressure in the eye. Correct healing of the flap is critical for the long term success of the procedure.
A cytotoxic antimetabolite is used to prevent closure of the flap, however, the treatment is associated with significant side effects. Clanotech’s mission is to improve the outcome of glaucoma surgery by the development of CLT-28643 and thereby replace non-specific cytotoxic treatment with a target specific therapy that has an improved safety profile.
New Chemical Synthesis Process: Synergy of Two Catalysts in One FlaskNews
Researchers report the one-step synthesis of a ketone from an aldehyde by the combination of thiazolium N-heterocyclic carbene and palladium/bisphosphine catalysts in one flask. The two catalysts function in a synergistic manner. This study is expected to lead to new synthesis processes of precursor compounds for medications.READ MORE
Synthesis of Drug-Like Molecules Simplified Using New Cross-Coupling MethodNews
Researchers have designed a new molecule-building method. The technique, described recently in the journal Science, paves the way toward other new chemical reactions and facilitates the synthesis of pharmaceutically-relevant molecules.READ MORE
Domainex Appoints Dr Bodo Spori as Head of Business Development for EuropeNews
Domainex Ltd, a privately-owned drug discovery services company, is pleased to announce the appointment of Dr Bodo Spori as Head of Business Development for Europe.READ MORE
Comments | 0 ADD COMMENT
World Congress on Advanced Pharmacy and Clinical Research
Jul 16 - Jul 17, 2018
10th International Conference on Mass Spectrometry and Chromatography
Oct 08 - Oct 09, 2018