CNS Inflammation: A Pathway and Possible Drug Target
News Apr 12, 2016
Now, Yale researchers have identified a mechanism that offers this new insight into this protective effect.
Until now, the prevailing theory has been that the blood brain barrier provided the protective effect by preventing immune cells and molecules from entering the brain. However, when inflammation does occur, the brain has a way other than the blood brain barrier of slowing or stopping it, the Yale team observed
Just as humans communicate using language, cells communicate using cell surface molecules and soluble proteins. And it is a particular conversation between a protein known as HVEM (herpes virus entry mediator) and SALM5, a molecule mainly found in neuronal cells, that suppresses CNS inflammation, said senior author on the paper, Lieping Chen, MD, PhD United Technologies Corporation Professor in Cancer Research, professor of immunobiology, dermatology, and medicine (medical oncology); and co-director, cancer immunology program at Yale Cancer Center.
“We’ve identified a key molecular pathway that may control CNS inflammation and provide evidence that this pathway could be manipulated by a monoclonal antibody to enhance immune response,” Chen said. “Also, we developed a new receptor array technology to identify the interaction between HVEM and SALM5. Both discoveries could be applied to the study of other pathways in the search for new therapies.”
Chen said his team’s interpretation opens the way for new drugs that can control CNS disease, including brain tumors. Specifically, using a strategy similar the anti-PD1/anti-PDL1 therapy developed in his lab many years ago to promote immune response in other human cancers.
T Cells Attack and Kill Dopamine-Producing Cells in Parkinson's diseaseNews
Researchers in Germany discover a potential new target for treating Parkinson's diseaseREAD MORE
Working Together Helps Phage Overcome CRISPRNews
Surprising results show that phage join forces to overcome bacteria’s CRISPR -based immune defenses. Improved understanding of the interactions between phage and their bacterial hosts could help advance phage-based therapies and stimulate viral research.READ MORE
Study in Mouse Model of Autism Finds Mother's Microbiome Determines RiskNews
The microbiome is the collection of microorganisms, such as bacteria, that naturally live inside us. New research in a mouse model suggests the microbiome determines autism risk.READ MORE