Compugen Announces Discovery of Biomarkers for Early Pre-Clinical Detection of Drug-Induced Kidney Toxicity
News Jun 30, 2008
Compugen Ltd. has announced the discovery and experimental confirmation of a novel combination of four biomarkers for early detection of drug-induced nephrotoxicity.
Data demonstrate that the biomarker signature may enable a much earlier prediction of drug-induced kidney toxicity during pre-clinical trials in rats in comparison to traditional diagnostic methods such as histopathology or clinical chemistry.
“Improved pre-clinical biomarkers for kidney toxicity would dramatically reduce the time and costs required to prioritize and select lead candidates for progression through drug development stages,” said Anat Cohen-Dayag, Ph.D., Vice President of Diagnostic Biomarkers and Drug Targets at Compugen Ltd.
The biomarkers were discovered through the use of Compugen’s Nucleic Acid Testing (NAT) Discovery Platform. A key component of the discovery effort was the integration of proprietary expression and clinical data derived from biological samples provided by Teva Pharmaceutical Industries Ltd.
These samples were generated by Teva in a preclinical study designed specifically for this project pursuant to a Collaborative Research Agreement between Compugen and Teva.
Using various expression profile datasets, as well as statistical and machine-learning tools, a classifier consisting of a novel combination of four biomarkers was identified with a sensitivity of 80% and a specificity of more than 85%.
We’ve all heard the expression: “what doesn’t kill you makes you stronger.” Now, research suggests why, at a cellular level, this might be true. Brief exposures to stressors can be beneficial by prompting the cell to trigger sustained production of antioxidants, molecules that help get rid of toxic cellular buildup related to normal metabolism.