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Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors


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Abstract
The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.

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The article First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors is published online in the Journal of Flow Chemistry and is free to access. 

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