Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors
The first continuous flow carbonylation reaction using aryl formates as CO precursor is reported. The reaction is practical, scalable and high yielding. The use of a flow protocol safely allows expanding the scope to activated chlorides, nitrogen heterocycles and to the selective introduction of an ester group in dihalo-derivatives. Further selective reduction of the ester formed to an aldehyde in flow is also described.
The article First Example of a Continuous-Flow Carbonylation Reaction Using Aryl Formates as CO Precursors is published online in the Journal of Flow Chemistry and is free to access.