Continuous-Flow Catalytic Asymmetric Hydrogenations: Reaction Optimization Using FTIR Inline Analysis
News Apr 17, 2012
The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities.
The article is published online in Beilstein Journal of Organic Chemistry and is free to access.
Catalysis is common in many industries such as pharmaceutical, specialty chemicals, agriculture, polymer and over 90% of chemicals are made from catalytic processes. Researchers have reported an asymmetric reaction that uses a cationic (positively charged) catalyst to convert racemic (equal mixture of two enantiomers) substrates to asymmetric product via an intriguing reaction route,READ MORE