Creating More Potent Vaccines
News Jul 08, 2015
The new insight gets researchers one step closer to developing vaccines that could be more protective against some of the most intractable viral infections, including HIV and flu.
For the study researchers Brian Laidlaw, Dr. Joseph Craft, and Dr. Susan M. Kaech and co-authors observed immune responses to infection in mouse models. They found that a chemical signal known as IL-10, which is secreted by regulatory T cells, is important for the development of long-term immunity.
IL-10 is particularly important for keeping inflammation in check during the resolution phase of infection. By reducing inflammation during this phase, IL-10 enabled long-term memory cells — CD8+ T cells — to mature and develop their capacity to protect against future infection.
The finding may hold the key to more effective vaccines. “A critical problem with many vaccines is that they do not elicit a robust and protective T cell response,” said Laidlaw. The study sheds light on another pathway for enhancing the body’s protective response. “By understanding this process, during each phase of the immune response, we hope to be able to mirror these steps in a vaccine approach,” he said.
Gene Regulator May Contribute to Protein Pileup in Exfoliation GlaucomaNews
Researchers are seeking factors that contribute to protein pileup in exfoliation glaucomaREAD MORE
T Cells Attack and Kill Dopamine-Producing Cells in Parkinson's diseaseNews
Researchers in Germany discover a potential new target for treating Parkinson's diseaseREAD MORE
Working Together Helps Phage Overcome CRISPRNews
Surprising results show that phage join forces to overcome bacteria’s CRISPR -based immune defenses. Improved understanding of the interactions between phage and their bacterial hosts could help advance phage-based therapies and stimulate viral research.READ MORE