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Evaluation of a Commercial Packed Bed Flow Hydrogenator for Reaction Screening, Optimization and Synthesis
Abstract
A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C catalyst bed, was used to examine performance at various pressure settings, over sequential runs, and with commercial catalyst cartridges. In addition, the consistency of the hydrogen flow was indirectly measured by in-line UV spectroscopy. Finally, system contamination due to catalyst leaching, and the resolution of this issue, is described. The impact of these factors on the run-to-run reproducibility of the H-Cube(®) reactor for screening and reaction optimization is discussed.
The article is published online in Beilstein Journal of Organic Chemistry and is free to access.
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