We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Evotec Announces the Successful Completion of the First Phase I Study with EVT 401
News

Evotec Announces the Successful Completion of the First Phase I Study with EVT 401

Evotec Announces the Successful Completion of the First Phase I Study with EVT 401
News

Evotec Announces the Successful Completion of the First Phase I Study with EVT 401

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Evotec Announces the Successful Completion of the First Phase I Study with EVT 401"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Evotec AG has announced the successful completion of the first Phase I study with its P2X7 receptor antagonist EVT 401. EVT 401 is a small molecule drug candidate and a potentially novel approach to orally treat inflammatory conditions such as Rheumatoid Arthritis.

The study was a double-blind, placebo controlled study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of EVT 401. A total of 96 healthy male volunteers received single oral ascending doses of the compound as a suspension or capsule.

The compound was very safe and well tolerated and there were no serious adverse events or withdrawals. In addition, the pharmacodynamic assay used in this study demonstrated the ability of EVT 401 to block ATP-stimulated IL-1ß release in whole blood samples taken from subjects, thereby proving “on target” activity at well tolerated oral doses.

In Rheumatoid Arthritis, the first potential indication for EVT 401, there is a significant need for new oral therapies. Oral drugs can be used both as alternatives to and in combination with existing agents to increase the responder rates and potentially reduce or delay the need for expensive bio-logical therapies.

Dr Werner Lanthaler, Chief Executive Officer of Evotec, commented: “We are encouraged that EVT 401 showed positive results in its first human trial. It was well tolerated and demonstrated the desired pharmacodynamic activity in healthy volunteers. We are now focussing our efforts on optimizing the oral dose formulation, completing the Phase I studies, and preparing Phase II studies in Rheumatoid Arthritis.”
Advertisement