Genomic Screening Approach Developed to Aid Drug Discovery

Prof. Dr Mikhail Yakimov, a researcher from the Immanuel Kant Baltic Federal University, together with his colleagues from the Heinrich Heine University Düsseldorf, Norwegian Research Centre NORCE AS, School of Natural Sciences of CEU San Pablo University and Institute of Catalysis and Petrochemistry in Madrid (Spain), has conducted a study of universal transaminase enzymes. These ferments are involved in cellular metabolism and they also play a key role in construction of building blocks of cells.

Different chemical substances, which are used in drugs, should have a special property that is necessary for the most important molecular compounds of human body. This property is called chirality, and it is based on molecular symmetry elements. Chirality of a compound can differ from its chemical formula. There are only D-sugars and L-amino acids and no D-amino acids in human body.

The researchers have found out that transaminases are the enzymes, which can synthesize the compounds with special chirality. Today, there are many ways to detect transaminases of different chemical compositions.

Recently, a new approach for genomic and metagenomic screening has been developed. The researchers have identified 10 genes, which encode transaminases.

This article has been republished from materials provided by Immanuel Kant Baltic Federal University. Note: material may have been edited for length and content. For further information, please contact the cited source.

reference: Cristina Coscolín, et al. Bioprospecting Reveals Class III ω-Transaminases Converting Bulky Ketones and Environmentally Relevant Polyamines. Appl Environ Microbiol. (2019) DOI: 10.1128/AEM.02404-18.