A drug used to treat gout, probenecid, may improve heart function in individuals with a particular heart defect, according to results from a small pilot study run by a University of Cincinnati researcher.
Jack Rubinstein, MD, associate professor in the UC College of Medicine and UC Health cardiologist, conducted a randomized double-blind trial which included eight participants who had palliative surgery to correct a condition of the heart known as congenital univentricular circulation. Each participant received probenecid or a placebo during a 12-week period.
As part of the study, Rubinstein and co-investigators at Cincinnati Children’s Hospital recruited patients to receive either probenecid or a placebo for four weeks followed by a four-week period without medication. They were then required to undergo another four weeks of alternate treatment. All patients were assessed at baseline immediately preceding the initial use of probenecid or the placebo. This included symptom reporting, heart imaging and exercise testing to determine aerobic capacity and endurance.
The study findings are available online in the scholarly journal Pediatric Cardiology.
“Heart function in participants along with their symptoms improved as a result of the pilot study,” says Rubinstein. “Heart contractility was better. It wasn’t a huge increase but enough for us to be able to detect it. They ran better and their heart pumped better. We observed a small change, partially because there were a small number of people involved.”
“We can repurpose this medicine, long used to treat gout, to improve how the heart works for kids with univentricular circulation without any adverse effects,” says Rubinstein. “The next step is a larger study to prove we can make it work safely in the long term.”
Probenecid has been shown in recent years to positively influence cardiac function via effects on the Transient Receptor Potential Vanilloid 2 (TRPV2) channel in cardiomyocytes, explains Rubinstein. Researchers observed an improvement in cardiac function and exercise performance with probenecid in patients with a functionally univentricular circulation.
This study also reported work with colleagues at the University of Colorado that showed that patients with single ventricle physiology had higher levels of TRPV2 in their hearts, while collaborators at Oslo University Hospital reported a novel mechanism through which probenecid may particularly be helpful in this patient population.
Univentricular heart (UVH) is a severe congenital cardiac malformation characterized by one functional chamber. The clinical manifestations include congestive heart failure, failure to thrive, cyanosis, hypoxemia and neurodevelopmental disabilities.
Other co-authors on this study including Jessica Woo, PhD, UC research professor of pediatrics; Anastacia Garcia, Children’s Hospital Colorado; Tarek Alsaied, MD, UC assistant professor of pediatrics and Cincinnati Children’s Hospital Medical Center physician; Ryan Moore, MD, UC assistant professor of pediatrics and Cincinnati Children’s physician; Amanda Sammons, Cincinnati Children’s researcher; Wayne Mays, Cincinnati Children’s researcher; Shelley Miyamoto, MD, Children’s Hospital Colorado; Gruschen Veldtman, MD, Cincinnati Children’s physician; and Jia Li, Per Kristian Lunde, Martin Laasmaa and William Louch, all of Oslo, Norway.
Reference: Rubinstein J., Woo JG., Garcia AM. et al. Probenecid improves cardiac function in subjects with a fontan circulation and augments cardiomyocyte calcium homeostasis. Pediatr Cardiol. 2020. doi:https://doi.org/10.1007/s00246-020-02427-7
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