Herbal Products Could Compromise Prescription Drugs and Cause Serious Side Effects
An analysis of published studies and reports indicates that a number of herbal products may affect the properties of prescription drugs, leading to alterations in the drugs' effectiveness as well as potentially dangerous side effects.
The British Journal of Clinical Pharmacology analysis included 49 case reports and two observational studies with 15 cases of adverse drug reactions. The majority of patients were diagnosed with cardiovascular diseases, cancer, and kidney transplants and were receiving mostly warfarin, alkylating agents, and cyclosporine, respectively.
Investigators noted that patients taking warfarin and/or statins for the treatment of cardiovascular complications reported significant interactions after taking herbal products including sage, flaxseed, St. John's wort, cranberry, goji juice, green tea, and chamomilla.
This article has been republished from materials provided by Wiley. Note: material may have been edited for length and content. For further information, please contact the cited source.
Awortwe, C., Makiwane, M., Reuter, H., Muller, C., Louw, J., & Rosenkranz, B. (2018). Critical Evaluation of Causality Assessment of Herb-Drug Interactions in Patients. British Journal of Clinical Pharmacology. doi:10.1111/bcp.13490
A new study by investigators from Brigham and Women’s Hospital examined whether pregnancy-related changes may influence how effectively five common AEDs prevent seizures and found that antiepileptic drug clearance significantly changes by the first trimester for the most commonly used medication and by the second trimester for two others.READ MORE