High-throughput Evaporation of Strongly Acidic Chemicals
News Jul 14, 2005
Genevac has announced that a new version of the HT-12 Series II system has been introduced to provide laboratories with a highly efficient and safe means of routinely removing strongly acidic chemicals from their samples. The HT-12 HCl system enables chemists to evaporate high concentrations of HCl, achieving cleaner synthesis and de-protection than using other acids, such as trifluoroacetic acid.
According to Genevac, the design of the HT-12 HCl system presents real advantages for all chemists faced with removing both regular solvents and strongly acidic chemicals. The HT-12 HCl uses inert and corrosion proof materials to enable high concentrations of hydrochloric acid and other acid chlorides to be removed without any loss of performance or long-term deterioration in the system.
These include a PTFE coated evaporation chamber, a glass condenser with FEP tubing and all metallic parts coming into contact with removed solvent manufactured from highly durable and acid resistant Hasteloy C2000 steel. In addition the system is configured with Genevac's high performance scroll pump. The main advantage of this reliable pump technology is that it does not require any pumping fluid or lubricant in order to operate. This makes the new HT-12 HCl system ideal for use in harsh chemistry environments where corrosive or volatile solvents are frequently used.
The HT-12's high performance and high sample capacities make it an ideal workhorse for applications including combinatorial chemistry, parallel synthesis, LC/MS purification, compound purification, plate re-formatting, and plate replication that require high throughput evaporation. The unique design of the multi layer rotor ensures efficient use of valuable laboratory bench space as well as providing high performance and efficient evaporation.
The HT-12 system accommodates a wide range of sample formats. The strong rotors are housed in a cast aluminium vacuum chamber, protected from attack by corrosive vapours by a reinforced perfluorinated coating. The rotors incorporate 12 "sample swings" to accommodate Genevac sample holders for tubes & vials, microtitre plates and custom sample formats.
Proprietary control software allows the HT-12 to automatically detect when the samples are dry and then shut it down - safeguarding valuable samples from potential thermal degradation. The 'auto stop when dry' function allows easy unattended operation offering the possibility of significant increases in productivity through use of overnight evaporation runs.
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