We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
ImmunoGen Announces Positive Data with IMGN901 Compound in the Treatment of Small-Cell Lung Cancer
News

ImmunoGen Announces Positive Data with IMGN901 Compound in the Treatment of Small-Cell Lung Cancer

ImmunoGen Announces Positive Data with IMGN901 Compound in the Treatment of Small-Cell Lung Cancer
News

ImmunoGen Announces Positive Data with IMGN901 Compound in the Treatment of Small-Cell Lung Cancer

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "ImmunoGen Announces Positive Data with IMGN901 Compound in the Treatment of Small-Cell Lung Cancer"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

ImmunoGen, Inc. has announced the presentation of encouraging initial efficacy, safety and tolerability clinical data with its IMGN901 product candidate in the treatment of small-cell lung cancer (SCLC).

In two early-stage clinical trials that enrolled patients whose SCLC had recurred following treatment with standard chemotherapies, IMGN901 administration achieved notable tumor shrinkage and/or sustained stable disease.

The compound also demonstrated encouraging activity against other CD56-expressing (CD56+) solid tumors. These clinical data are being presented at the 13th World Conference on Lung Cancer taking place in San Francisco, CA, from July 31 to Aug. 4, 2009.

IMGN901 was created by ImmunoGen to kill tumors that express the CD56 protein targeted by the compound. It consists of a potent cancer-cell killing agent, DM1, attached to a CD56-targeting antibody, huN901, using an engineered linker. IMGN901 currently is in early clinical testing and is a potential treatment for SCLC, Merkel cell carcinomas, ovarian cancers, multiple myeloma, and other CD56+ cancers.

“We are encouraged by the initial efficacy and safety profile of IMGN901 in SCLC and Merkel cell carcinoma, especially as these cancers have proven highly challenging to treat,” stated Professor Penella J. Woll, MD, PhD, Weston Park Hospital, UK. “The data thus far indicate that IMGN901 offers potential for use in a number of indications, including several types of CD56-expressing solid tumors.”

The findings being presented at the 13th World Conference on Lung Cancer by Professor Woll come from the two IMGN901 trials that included SCLC patients. Study 001 (enrollment has closed) was open to patients with any type of CD56+ solid tumor, including SCLC, during its dose-escalation Phase I leg.

In its Phase II leg, enrollment was limited to patients with SCLC or other CD56+ small-cell carcinoma. In this trial, IMGN901 was administered weekly for four weeks every six weeks. Study 002 is a dose-escalation trial evaluating IMGN901 in patients with CD56+ solid tumors, including SCLC, when administered daily for three consecutive days every 21 days. In both trials, the SCLC must have recurred following previous treatment with standard therapies for a patient to qualify for enrollment.
Advertisement