ImQuest and Arisyn Announce Strategic Partnership to Develop Infectious Disease and Cancer Drugs
News Apr 30, 2009
ImQuest BioSciences and Arisyn Therapeutics jointly announced that they have entered into a strategic drug development partnership to provide support necessary to develop Arisyn's portfolio of novel inhibitors for the treatment of infectious disease and cancer.
Arisyn has recently announced its acquisition of a series of inhibitors with demonstrated preclinical efficacy against HIV, HCV, HTLV-I, influenza virus, herpes viruses and cancer. These inhibitors were originally discovered and developed by The Proctor & Gamble Company. Lead molecules from the portfolio have already been evaluated in Phase 1 human clinical trials for the treatment of HIV and cancer, and an IND-application has been prepared for submission to the FDA to initiate trials for HCV therapy.
"The Arisyn compounds represent an entirely new treatment paradigm by effectively suppressing the ability of the HIV or HCV-infected cells to act as the factories of progeny virus production," stated Robert W. Buckheit, Jr., Ph.D., Director of Research and Development for Arisyn and President and Chief Scientific Officer of ImQuest BioSciences. "The compounds have proven efficacy and safety in preclinical studies and their successful development will be of immense benefit to the millions of individuals living with HIV and HCV infection."
ImQuest BioSciences, a Contract Research service provider specializing in the discovery and development of anti-infective and anti-cancer agents, will provide all required support to initiate human clinical trials with lead products ATI-0312 for HIV and ATI-0810 for HCV and will initiate mechanistic studies to define the unique virus transcription inhibitory mechanism of action of the class of inhibitors. ImQuest will also lead Arisyn's efforts to develop next generation inhibitors from structure activity relationship studies and target-based drug design programs.
"This partnership is an important step in the development of our portfolio. ImQuest BioSciences brings a broad range of expertise and a wealth of experience to Arisyn," said Eric Zucco, President of Arisyn. "After years of pre-clinical evaluations, we now look to Imquest BioSciences to guide these compounds into and through human clinical trials."
Scientists from the UNC School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. The researchers also reported that the NLRP12 gene is underactive in people who are obese, making it a potential therapeutic target for treating obesity and diabetes.READ MORE