International Collaboration to Create New Cancer Models
News Jul 11, 2016
An international project to develop a large, globally accessible, bank of new cancer cell d culture models for the research community launched.
The National Cancer Institute (NCI), Cancer Research UK, the Wellcome Trust Sanger Institute and the foundation Hubrecht Organoid Technology are joining forces to develop the Human Cancer Models Initiative (HCMI) which will bring together expertise from around the world to make around 1,000 cancer cell models.
Using new techniques to grow cells, scientists can make models which will better resemble the tissue architecture and complexity of human tumours than the cell lines used today.
“As part of NCI’s Precision Medicine Initiative in Oncology, this new project is timed perfectly to take advantage of the latest cell culture and genomic sequencing techniques to create models that are representative of patient tumours and are annotated with genomic and clinical information. This effort is a first step towards learning how to use these tools to design individualised treatments.” – Dr Louis Staudt, director of NCI’s Center for Cancer Genomics
Scientists will make the models using tissue from patients with different types of cancer, potentially including rare and children’s cancers, which are often under-represented or not available at all in existing cell line collections.
“This exciting new project means that we can expand our resources for researchers around the world. We want scientists to have the best resources to be able to easily study all types of cancer. And these new cell lines could transform how we study cancer and could help to develop better treatments for patients.” – Dr Ian Walker, Cancer Research UK’s director of clinical research
The new models have the potential to reflect the biology of tumours more accurately and better represent the patient population.
The tumour and the derived models will be genetically sequenced. Researchers will have access to this information, as well as the anonymised clinical data about the patients and their tumour.
The HCMI collaborators aim to speed up development of new models and to make research more efficient by avoiding unnecessary duplication of scientific efforts.
“New cancer model derivation technologies are allowing us to generate even more and improved cancer models for research. A concerted and coordinated effort to make new models will accelerate this process, while also allowing for rapid learning, protocol sharing, and standardised culturing methods.” – Dr Mathew Garnett, group leader at the Wellcome Trust Sanger Institute
“We are delighted to take part in this global partnership to make new resources for researchers.” – Dr Hans Clevers of the foundation Hubrecht Organoid Technology
HCMI could transform research and will allow scientists to study many aspects of cellular biology and cancer, including how the disease progresses, drug resistance, and the development of precision medicine treatments.
Artificial Leaf Acts as a Mini Medicine FactoryNews
Using sunlight for sustainable and cheap production of, for example, medicines. The 'mini-factory' in the form of a leaf that was presented in 2016 showed that it is possible. Now researchers have come with an improved version: their 'mini-factory' is now able to keep production at the same level, irrespective of the variation in sunlight due to cloudiness or time of the day.READ MORE
Compound Offers Pain-relief of Opioids Without Addictive PropertiesNews
Researchers have engineered a new compound that animal tests suggest could offer the pain-relieving properties of opioids such as morphine and oxycodone without the risk of addiction.READ MORE
E. Coli’s Internal Bomb Offers Chink In ArmourNews
Bacteria's internal bomb, the so-called toxin-antitoxin (TA) system that is part of the normal bacterial makeup, may be triggered to make bacteria turn on themselves, providing a valuable target for novel antimicrobial approaches in drug design.READ MORE
Comments | 0 ADD COMMENT
15th Symposium on the Practical Applications of Mass Spectrometry in the Biotechnology Industry
Sep 09 - Sep 12, 2018
CE in the Biotechnology & Pharmaceutical Industries: 20th Symposium on the Practical Applications for the Analysis of Proteins, Nucleotides & Small Molecules
Sep 09 - Sep 12, 2018