Karo Bio and Wyeth Extend Research Collaboration
News Jul 03, 2007
The Swedish company Karo Bio has announced that Wyeth and Karo Bio extended their atherosclerosis collaboration for an additional year until August 31, 2008. The primary objective of the extension is to characterize back up compounds and to further evaluate additional clinical possibilities by targeting LXR.
The collaboration with Wyeth started in 2001 with the aim to develop compounds for treatment of atherosclerosis with LXR as target receptor. In August 2006 Wyeth entered phase I clinical development which triggered a milestone payment to Karo Bio.
“We are happy for continuing to work with Wyeth in our joint collaboration and we see great opportunities for compounds that target LXR”, says Per-Olof Wallström, President of Karo Bio.
LXR is a nuclear hormone receptor that is an important regulator of cholesterol metabolism in mammals. LXR has many features that make it an attractive drug development target for prevention and treatment of atherosclerosis and dyslipidemia.
Modulation of LXR with small molecule compounds has been demonstrated to enhance the efflux of cholesterol from cells in atherosclerotic blood vessels, resulting in a reduction in the progression of atherosclerotic disease in selected experimental models.
Modified Form of Botox Could Replace Opioids as Treatment for Chronic PainNews
A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects and, in time, could replace opioid drugs as a safe and effective way of treating chronic pain, according to new research.READ MORE
Key Ingredient in Diabetes Drug Modified to Improve Side EffectsNews
Improved medications for Type 2 diabetes are one step closer thanks to a new discovery reported this week. By modifying the key ingredient in current diabetes drugs, the researchers produced a compound that was effective for hyperglycemia in animal trials, yet without the most problematic side effects of current drugs.READ MORE
Tackling Cancer at Ground Zero: Designer Molecule Inhibits Protein TargetNews
A new molecule designed by University of Adelaide researchers shows great promise for future treatment of many cancers. The new molecule successfully targets a protein that plays a major role in the growth of most cancers.READ MORE