It is a library of venom fractions available in 96-well plates. Venoms have been first cleared from cytotoxic enzymes and split up in 20 fractions each. Wells are expected to contain 5 to 10 peptides so as to facilitate the identification of the active peptide once a hit is found out. Well-plates are filled with 80 fractions of 4 venoms, corresponding to about 500 different peptides in total.
The KITOXAN®-V01 Library is the first set of 5 well-plates of a total 400 venom fractions from 20 species: snakes, scorpions, amphibians, spider. In total KITOXAN-V01 allows the screening of pharmacological activity of over 2500 natural peptides.
Additional sets of well-plates will be progressively developped to give scientists a larger scope among venoms diversity. With 100’000 venomous species in the world and millions of potential hits for drug discovery it might be a long way for KITOXAN®.