Maas Biolab SBIR Enters Phase II for Cyclosporin ALS Treatment
News Dec 04, 2008
Maas Biolab has advanced to Phase II of its Small Business Innovation Research (SBIR) grant “Intrathecal Cyclosporin for the Treatment of Amyotrophic Lateral Sclerosis (ALS).”
Jenny Karlsson, Ph.D., is Maas Director of Preclinical Development and Principal Investigator of the $2.1 million three-year grant from the National Institute of Neurological Disorders and Stroke (NINDS).
After successful completion of Phase I established initial Mitogard® stability and drug safety for the new intrathecal route for cyclosporin, the amount of $894,000 for year two was released by the National Institutes of Health (NIH).
“The first year’s results show Mitogard® intrathecal safety in the therapeutic range, and we look forward with excitement to the second year’s more in-depth toxicology testing,” says Dr. Karlsson.
Phase II will complete the preclinical stability, toxicology and pharmacokinetics over the next two years to enable the first human clinical trials for Maas Biolab’s Mitogard® intrathecal cyclosporin formula.
The Veterans Administration Clinical Research Pharmacy Coordinating Center, Albuquerque, N.M., performs stability testing. Northern Biomedical Research, Muskegon, Mich., conducts the intrathecal testing.
Thirty thousand Americans have ALS. Progressive loss of motor neurons causes paralysis and death within three years. Injections of cyclosporin into the CSF bypass the blood brain barrier and extend survival in the SOD1 G93A transgenic ALS mouse at low non-immunosuppressive doses.
Worms Exhibit Fear and Respond to Anti-anxiety MedsNews
A team of investigators has uncovered new clues about the mechanisms of fear and anxiety through an unlikely creature: the tiny nematode worm.READ MORE
New Studies Demonstrate Risk Reduction Potential of Heat-Not-Burn Tobacco Products and e-CigarettesNews
Data presented at the Society of Toxicology Annual Meeting (SOT) have demonstrated the potential of two different heat-not-burn tobacco products and e-cigarettes to reduce the risk of smoking-related diseases, in comparison to continued use of conventional cigarettes.READ MORE
Low Temperatures Turn Stem Cells into Calorie-Burning FatNews
The secret to healthy eating may not be in freezer food, but low temperatures can help turn stem cells into brown fat, a type of fat which helps burn calories. A new study could turn this knowledge into weight-loss treatments.READ MORE