Mettler Toledo has announced initial shipments of the MultiGram®III Preparative SFC to two major pharmaceutical manufacturers in North America.
The MultiGram®III uses Berger SFC patented technology and is designed to increase throughput of chiral and achiral purifications by three to ten times over HPLC, while offering equivalent resolution and enhanced selectivity.
"As the only dedicated Supercritical Fluid Chromatography (SFC) instrument company, we made a concerted effort to listen to the feedback provided by our end users, and this product is a direct result," commented Dave Wetherell, SFC Marketing Manager, Mettler Toledo.
"As a third generation preparative SFC, this instrument offers expanded collection capacity, increased flow rate capability, near-atmospheric pressure collection, a visible waste train, and a number of advanced safety features."
"Celebrating over a decade in the field of SFC, this is the first integrated product developed utilizing a diverse team of individuals across a wide range of disciplines. We are quite proud of the outcome."
Offering flow rates of up to 400 ml per minute, the MultiGram®III is designed to accommodate an expanded range of high capacity preparative columns ideal for large scale purification.
The MultiGram®III allows the collection of automated sample fractions in four selectable volume containers with capacities from 1 liter to 20 liters, and includes two 20 liter solvent reservoirs as well as intrapeak collections into 2 to 10 liter vessels.
Selectable peak detection parameters provide the use of time windows, threshold, and slope, or a combination of all three parameters, enabling time-based yields of 95%, and an output of up to 30 grams per hour for each peak.