Mimicking a Sweet Solution Helps Drug Delivery & Distribution
The repeating regular hierarchical structures are shown by scanning electron microscopy (SEM) images that illustrate how the honeycomb structure has formed at the surface of the material. Credit: S. Nunes
A fast and safe method to prepare a 3D porous material that mimics the shape of a honeycomb could have broad applications from catalysis to drug delivery or for filtering air to remove pollutants or viruses.
Both the lattice of a honeycomb and the symmetry of a diatom are complex living structures comprising patterns and shapes that have long provided inspiration for scientists. One recent application is to develop artificial hierarchical porous materials that are stable, yet have a large surface area and the ability to selectively extract materials. It has been difficult however to build these structures at the nanoscale due to their complexity and pattern repeatability across scales from the individual compartments to the whole structure.
A team from KAUST, led by Suzana Nunes, has proposed a simple method that, in just five minutes, can produce a flexible film with a complex hierarchical structure that has repeating patterns of interconnected, regularly shaped pores.
With experts in the Imaging and Characterization Core Lab, the team used the block copolymer called polystyrene-b-poly (tertbutyl acrylate) (PS-b-PtBA) to demonstrate this method. They tested various concentrations of PS-b-PtBA with different solvent mixtures, cast the resulting solutions on glass plates and evaporated them for different time periods to promote the nucleation and growth of cavities with highly porous interconnecting walls. The resulting film was then immersed in water to rinse off the solvent and halt the phase separation.
"By using this method we create an important platform to design artificial porous materials that replicate highly ordered porous and complex systems mimicking nature," explains research scientist and lead author Stefan Chisca. "These have potential use for separations, such as virus filtration, and for biological scaffolds, such as those used for bone regeneration."
This article has been republished from materials provided by King Abdullah University of Science & Technology (KAUST). Note: material may have been edited for length and content. For further information, please contact the cited source.
Antitumor Immune Function in Liver Controlled by Gut MicrobiomeNews
Scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver. The study showed that bacteria found in the gut of mice affect the liver’s antitumor immune function. The findings have implications for understanding the mechanisms that lead to liver cancer and for therapeutic approaches to treat them.READ MORE
Tiny Particles Carry Tumor Shrinking Drugs into the BrainNews
MIT researchers have now devised a new drug-delivering nanoparticle that could offer a better way to treat glioblastoma. The particles, which carry two different drugs, are designed so that they can easily cross the blood-brain barrier and bind directly to tumor cells.READ MORE
Rapamycin Lotion Reduces Facial Tumors Caused by Tuberous SclerosisNews
Addressing a critical issue for people with a genetic disorder called tuberous sclerosis complex (TSC), doctors reported that a skin cream containing rapamycin significantly reduced the disfiguring facial tumors affecting more than 90 percent of people with the condition.READ MORE
Comments | 0 ADD COMMENT
2nd Annual Artificial Intelligence in Drug Development Congress
Sep 20 - Sep 21, 2018