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Molecular Mechanisms of Ancient Herbal Remedies

News   Nov 16, 2018 | Original story from University of California, Irvine

 
Molecular Mechanisms of Ancient Herbal Remedies

UCI researchers reveal how two components of the Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs, including the heart, kidneys, gastrointestinal tract, thyroid and pancreas. This computer model illustrates the novel herbal component, CPT1, an isovaleric acid molecule (green), occupying a novel binding site (R243, red) to activate KCNQ1. Credit: UCI School of Medicine/Geoff Abbott

 
 
 

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